15260-10-3 Tert-butoxycarbonyl-L-threonine(benzyl)-OH

Budada crystalline cad;Aan ku milmin biyaha iyo ether batroolka, oo ku milma ethyl acetate iyo methanol;mp waa 115-116 ℃;Wareeg gaar ah [α]20D+15.8°(0.5-2.0 mg/ml, methanol).
Waxaa loo isticmaalaa isku-dhafka polypeptide, sida monomer ilaalinta amino acid.
O-benzyl-l-threonine ayaa lagu hakiyay xalka dioxane waxaana lagu shubay tert-butylcarbonyl azide si loo helo badeeco cayriin ah, kaas oo laga soo saaray ethyl acetate pH ee 9-10 ka dibna dib loo celiyay.
Qayb firfircoon oo ka mid ah thymic oietin Ⅱ ee dheecaanka thymus.Thymoietin II waa hal unug oo polypeptide ah oo ka go'an hormoonka thymus.Waxay ka kooban tahay 49 amino acids, iyo jajabka silsiladda peptide ee ka kooban 5 amino acids waxay leeyihiin dhammaan hawlaha jireed ee isku midka ah sida thymoietin II.Sidaa darteed, jajabkan pentapeptide waxaa loo yaqaan thymus pentapeptide.Cadaan baraf-qalalan oo dabacsan ama budo ah.
Mid ka mid ah doorarka thymus pentapeptide waa in la kiciyo kala soocida unugyada T.Waxay si xushmad leh u kicin kartaa isbeddelka unugyada Thy-1-prothorax unugyada Thy-1+ T.Kala soocida unugga T waxaa dhexdhexaadiya heerarka cAMP ee unugyada unugyada oo kordhay.Shaqada kale ee aasaasiga ah ee thymus pentapeptides waa in lagu xidho reseptors gaar ah oo ah unugyada dhiiga durugsan ee bislaaday, kordhinta heerka cAMP intracellular, oo sidaas darteed u horseedo taxane falcelin unugyada gudaha ah, taas oo sidoo kale ah saldhigga hawsheeda immunomodulatory.Xaaladda jirka ee caadiga ah, thymus pentapeptide waxay muujisay saameyn kicinta difaaca jirka, taas oo si weyn u kordhin karta heerka E rosette formation iyo heerka beddelka ee lymphocytes splenic, kor u qaadida heerarka kala duwan ee jawaabta difaaca aasaasiga ah ama sare, iyo kordhinta tirada IgM nooca iyo IgG ama Unugyada samaysmaya nooca IgA.Thymus pentapeptide wuxuu sidoo kale wanaajin karaa shaqada phagocytosis ee macrophages, kordhinta enzyme iyo phagocytosis ee polymorphonuclear neutrophils, waxay kordhisaa maadada difaaca jirka ee wareega wareega, waxayna wanaajisaa shaqada difaaca unugyada cas cas.Thymus pentapeptide wuxuu dhaqaajin karaa CD4 iyo CD8 unugyo togan, si unugyo gaar ah oo Tc ah ay u sii hayaan nolol dheer, laakiin sidoo kale waxay dhaqaajiyaan unugyada Th oo ay kiciyaan shaqada unugyada Ts.Saamaynta ka-hortagga caabuqa iyo daaweynta ee thymus pentapeptide waxay la xiriirtaa kor u qaadida waxqabadka unugyada TC.Qadarka habboon ee thymus pentapeptide wuxuu si weyn u kordhin karaa wax soo saarka interferon ee ka hortagga caabuqa.Keenista iyo kor u qaadida kala-duwanaanta unugyada T unugga iyo korriinka;CD4/CD8 waxay u janjeertay inay caadi noqoto iyadoo nidaamisa saamiga T lymfosayt-ka hoose;Kobcinta shaqada phagocytosis ee macrophages;Kor u qaad shaqada difaaca unugyada dhiigga cas;Kordhi shaqada unugyada dilaaga dabiiciga ah;Kordhi heerka soosaarka interleukin-2 iyo muujinta soo-dhoweynta;Kobcinta wax soo saarka γ interferon ee unugyada mononuclear-ka ee dhiigga;Kordhi dhaqdhaqaaqa SOD ee serum
Waxaa loo isticmaali karaa bukaanada buro-xumada leh ee leh daciifnimo shaqada difaaca ka dib daaweynta shucaaca iyo kiimoterabiga.Daawaynta cagaarshowga B;Qalliinnada waaweyn ee qalliinka iyo caabuqyada daran;cudurada autoimmune sida rheumatoid arthritis, lupus erythematosus;Nooca II ee sonkorowga mellitus, cilladda menopause;Qofka difaaca jirkiisu daciif yahay.