22254-24-6 8-Isopropylatropinium bromide

Ipratropium bromide waxaa sidoo kale loo yaqaan Haizhupanidine, isopropyl atropine, isopropyl scopolamine, isopropyl atropine, ipratropine bromide, isopropyl atropine bromide, ipratropine bromide, ipratropium bromide, ipratropium bromide.Waa budo crystalline cad oo dhadhan qadhaadh leh.Barta dhalaalka 232 ℃-233 ℃.Ku milmay biyaha, wax yar ku milma ethanol, aan milmin karin dareerayaasha kale ee dabiiciga ah.Magaca kiimikada: Brominated α-(hydroxymethyl) -phenylacetic acid - 8-methyl-8-isopropyl - azocyclic [3,2,1] -3-octyl ester.Waa daawada anticholinergic, taas oo saameyn nasasho xoog leh ku leh murqaha siman ee bronki iyo saamaynta antiasthmatic ee cudurrada sambabada xanniba ee joogtada ah.Saameynteedu waa mid cad, saameyn degdeg ah iyo muddada dheer.Ipratropium bromide sidoo kale waxay xakameysaa dheecaanka qanjidhada xabka waxayna wanaajisaa dhaqdhaqaaqa ciliary, sidaas darteed waxay yareysaa xannibaadda xaakada si loo hagaajiyo hawo-qaadista.Dhanka kale, dhimista xaakada waxay sidoo kale yaraynaysaa bronchospasm ee ay keento xanaaqa bronki.Kahortagga iyo daawaynta xiiqda bronki iyo neefta daba-dheeraada, gaar ahaan bukaanada aan u dulqaadan karin isticmaalka gariir muruqa β-agonist, tachycardia.Alaabtan waxaa loo isticmaali karaa in lagu daro beta-agonists si kor loogu qaado waxtarka midba midka kale, sida marka lagu daro finoterol si loo sameeyo aerosol (BERODU - AL) neefta, boronkiitada raaga iyo emphysema.Marka la barbar dhigo kiciyeyaasha receptor β-adrenergic (tusaale, isopropyl epinephrine), alaabtani waxay leedahay saameyno yar oo wadnaha ah, marka la barbar dhigo β2-receptor stimulants (tusaale, Suquanling), badeecadani waxay leedahay saameyn sharciyeed oo xoogan oo ku saabsan mugga xaakada.
buufin neefsashada40 ~ 80μg hal mar, 2 ~ 4 jeer maalintii.Markaad isticmaalayso, marka hore ka saar fur furka daboolka, saar daboolka isha iskutallaabta ee sanbabada, dhalada u rog, ka saar qolofka daboolka afka, ujeedo cunaha, nuugi gaaska isla mar, riix baska. waalka dushiisa, ku neefso dareeraha, neefta ku qabo in yar.Ku celi suunka kore hal mar haddii loo baahdo.Aerosol: 0.025% xal.Kiniinka: 10mg/kiniin.
Sunta daran ee anticholinergic waxaa lagu daweyn karaa cholinesterase inhibitors.
Dareen-celinta xun ee ipratropium bromide waxay la mid tahay atropine, taas oo keeni karta garaaca wadnaha, madax-xanuun, dawakhaad, dareemo, lallabbo, matag, calool xanuun, gariir, aragga oo qallafsan, afka qalalan, qufac, dysuria, sii xumeynta calaamadaha neefsashada iyo finan.
Ipratropium bromide waa muscarinic antagonist, bronchodilator, iyo cusbada isopropyl ee AtropineN.
Ipratropiumbromide iyo Formoterol ayaa qayb ahaan la isku daray si ay sambabada uga ilaaliyaan caabuqa joogtada ah iyo balaarinta sambabada, yaraynta neutrophils iyadoo la xakameynayo dhaqdhaqaaqa iyada oo loo marayo MMP-9.Ipratropiumbromide (1nM) waxay si weyn u kordhisay kalsiyum bromide, hoos u dhaca kala firdhinta hore iyo kordhinta annexin-V xidhitaanka.Ka dib daawaynta Ipratropiumbromide, hemolysis wax yar ayaa kordhay laakiin aad u weyn.Ipratropiumbromide waxay sababtaa dhimashada unugyada dhiigga cas ee isdilka ama eryptosis, ugu horreyntii sababtoo ah kicinta calcium.
Neefsashada budada qalalan ee Ipratropium (DPI) waxay ahayd bronchodilator wax ku ool ah oo fardaha lagu nasto ee qiyaasta 2400 mg / faras, iyada oo saameyn yar ku leh caliber hawada sare ee hawada inta lagu jiro soo kabashada.Jiirka lagu daweeyay cadmium, Ipratropium ayaa si aad ah u yareeyay qulqulka unugyada caabuqa ee parenchymal waxaana lagu arkay nabarada sambabada ee la xidhiidha ciriiriga.Ipratropium waxay qayb ahaan ka ilaalisaa sambabada caabuqa iyada oo la dhimayo dhexgalka neutrophils.Gudaha doofaarka guinea ee muruqa siman ee jilicsan, Ipratropium waa antagonist kaas oo xannibaya soo-dhoweynta muscarinic-ka-hortagga ah ee dareemaha parasympathetic sambabada.Ipratropium ayaa sidoo kale lagu muujiyay inuu yahay antagonist awood leh oo ka dambeeya oo ku xiran soo-dhoweeyayaasha xakameynaya muscarinic.Ipratropium waxay yaraynaysaa isbeddelada ugu badan ee cadaadiska xabadka waxayna kordhisaa u hoggaansanaanta firfircoon (Cdyn) ee neefsashada bararka (kordhinta Pplmax) iyo iska caabbinta sambabada (RL) ee fardaha.