130622-05-8 Tert-butoxycarbonyl-D-glutamic acid (methyl ester) -methyl ester

Fluoroquinolones waxay leeyihiin spectrum bakteeriyada ballaaran, firfircoonida bakteeriyada xooggan, falcelin xun oo hooseeya, nudaha nudaha wanaagsan, bioavailability afka sare, muddada maamulka oo dheer iyo maamul habboon.Caadi ahaan waxaa loo isticmaalaa daawaynta cudurrada faafa sida caabuqa mareenka neef-mareenka iyo caabuqa kaadi mareenka.Qaab dhismeedka dawooyinka bakteeriyada fluoroquinolone waxaa lagu gartaa joogitaanka fluorine ee booska lixaad ee quinolone nucleus waalidka.
Si kastaba ha noqotee, 10kii sano ee la soo dhaafay, sababtoo ah cadaadiska xulashada ee ka soo baxa codsiga ballaaran ee daawooyinka noocan oo kale ah, noocyada daawooyinka u adkaysta ayaa kor u kacaya, gaar ahaan sanadihii ugu dambeeyay, quinolone u adkaysta Streptococcus pneumoniae waxay leedahay iska caabin ah, taas oo u adkaysata penicillin. Antibiyootikada macrolide iyo antibiyootiga quinolone.Isla mar ahaantaana, waxaa la ogaaday in qaar ka mid ah fluoroquinolones ay sababi karaan kordhinta muddada QTc ee electrocardiogram, hepatotoxicity iyo phototoxicity, taas oo xaddiday codsigooda.
Si looga gudbo cilladaha kor ku xusan ee fluoroquinolones, waxaa degdeg ah in la sameeyo xeryahooda dhismeed cusub oo leh firfircooni bakteeriyada wanaagsan, bakteeriyada ballaaran ee bakteeriyada iyo sida ugu yar ee falcelinta xun ee bakteeriyada u adkeysata daawooyinka badan.Daawooyin taxane ah oo dhawaan la sameeyay fluoroquinolone-free (NFQ) oo ay ku jiraan 8-methoxyl way ka duwan yihiin antibiyootiga fluoroquinolone sababtoo ah ma laha fluorine booska 6 ee nukleus waalidka quinolone, laakiin wali waxay leeyihiin firfircooni firfircoon oo bakteeriyada ah.nemonoxacin waa NFQ cusub oo bakteeriyada topoisomerase inhibitor ah oo door ah.
Marka la barbardhigo fluoroquinolones-yada hadda suuqa ku jira, Nenofloxacin waxay u taagan tahay nooc cusub oo dawooyin dhisme ah.nemonocacin (TG-873870), oo ah dawo quinolone cusub oo ay soo saartay Procter & Gamble (P&G), waxay muujisay firfircooni bakteeriyada lidka ku ah noocyo kala duwan oo cudur-keenaha kiliinikada ah, oo ay ku jiraan Staphylococcus aureus iyo Streptococcus pneumoniae u adkaysta daawooyinka badan.Natiijooyinka tijaabada ee jiirarka cudurka qaba ayaa muujiyay in saamaynta bakteeriyada bakteeriyada ee alaabtani ay ka xoog badan tahay inta badan quinolones-ka hadda jira.Intaa waxaa dheer, alaabtu waxay leedahay sifooyin farmashiye oo aad u fiican oo si fiican loo dulqaatay.