Shiinaha 67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester Soo saaraha iyo Warshada |Jiayinglai

67630-00-6 Tert-butoxycarbonyl-4-NO2-phenylalanine-ethyl ester

Sharaxaad Gaaban:

Muuqashada	Karistayaal cad ama Off-cad ama budada crystalline.
MF	C16H22N2O6
MW	338.36
daahirnimo	98+

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shahaado
COA, HPLC, GC, HNMR, Assay, Content Water(KF), TLC diyaar ah

La mid ah

(S) -ethyl 2- (tert-butoxycarbonylaMino) -3- (4-nitrophenyl) propanoate;
Boc-(4-NO2)-L-Phe-OEt;
Boc-(4-NO2)-Oet;
Boc-Phe(4-NO2)-Oet;
L-Phenylalanine;
N-[(1,1-dimethylethoxy)carbonyl]-4-nitro-, ethyl ester

Baakad gudaha ah

Caadi ahaan waxaa loo isticmaalaa in lagu xidho budada.Waxayna ka hortagi karaan qorraxda iyo biyaha inay xumaadaan.

xirxirida dibadda

Kartoonka adag wuxuu ka ilaalin karaa alaabtaada inay shil galaan oo ay qoyaan.

Codsiyada

Nidaanib, waa kiimiko.Magaca kiimikada 1 h - indole - 6 - karboksilic acid, 2, 3 - dihydro - 3 - [[4 - (methyl [(4 - methyl - 1 - piperazine) acetyl] amino] phenyl] amino] benzene wadnaha ee methyl] - 2 - oxygen -, methyl ester, (z) - Clinically, alaabta this waxaa loo isticmaalaa in lagu daweeyo idiopathic pulmonary fibrosis (IPF).
Nidanib waxa uu dersay 1,529 bukaan oo qaba idiopathic pulmonary fibrosis (IPF) tijaabooyin caafimaad oo badan.Xogta badbaadada ee la soo bandhigay waxay ku salaysan tahay isbarbardhigga bukaanada 1061 ee la siiyay nidanib 150 mg laba jeer maalintii iyo placebo laba marxaladood oo 52-usbuuc ah 3, randomized, double-inard, placebo-controlled studies (INPULSIS-1 iyo INPULSIS-2).Dhacdooyinka xun xun ee ugu badan ee la xidhiidha isticmaalka nidanib waxaa ka mid ah shuban, lallabbo iyo matag, calool xanuun, cunto xumo, miisaan lumis, iyo enzymes beerka oo sarreeya.Fadlan tixraac [Taxadarka] maaraynta falcelinta xun ee u dhiganta.Kala soocidda xubnaha habaysan (SOC) ee MedDRA waxay bixisaa soo koobida falcelinta xun iyo kala soocida inta jeer.
Nidanib waa substrate-ka P-gp (eeg Pharmacokinetics).Daraasad gaar ah oo ku saabsan isdhexgalka daroogada, isku-darka maamulka ketoconazole, P-gp inhibitor awood leh, kororka soo-gaadhista nidanib ilaa 1.61 jeer aagga ka hooseeya qalooca (AUC) iyo 1.83 jeer xoojinta ugu sarreysa (Cmax).
Daraasadda isdhexgalka daroogada ee P-gp inducer rifampicin ee xoogga leh, soo-gaadhista nidanib ayaa hoos u dhacday 50.3%, sida lagu cabbiray aagga qalooca (AUC), marka lagu daro rifampicin marka la barbar dhigo Nidanib oo keliya.Marka la eego feejignaanta ugu sarreysa (Cmax), waxay hoos ugu dhacday 60.3%.
Marka lagu daro badeecadan, P-gp inhibitors (tusaale, ketoconazole ama erythromycin) waxay kordhin karaan soo-gaadhista nidanib.Xaaladahan, dulqaadka bukaanka ee nidanib waa in si dhow loola socdo.Maareynta falcelinta xun waxay u baahan kartaa joojinta, dhimista qiyaasta, ama joojinta daawaynta alaabtan (eeg [Isticmaalka iyo qiyaasta]).
Soo-saareyaasha awoodda leh ee P-gp (tusaale, rifampicin, carbamazepine, phenytoin iyo St. John's wort) waxay yarayn karaan soo-gaadhista nidanib.Isku darka kale ee aan lahayn ama ugu yar ee P-gp waa in la tixgeliyaa.

alaabta la xidhiidha

Gly-Phe	Boc-Phe-Gly-Ome	HN-Me-L-Phe.Hcl	Boc-D-Phe-D-Phe
Boc-D-4-Chloropheny(alanine)	Fmoc-L-Phe-OH	L-Phe-NH2.Hcl	Boc-Phe-Gly
L-Ala-Phe-OH	Fmoc-D-Phe-OH	4-NO2-Phe-Oet	Boc-L-Phe-Onp
Boc-Ala-Phe-OH	Fmoc-N-Me-L-Phe-OH	4-NO2-Phe-Oet.HCl	Boc-L-Phe-Oet
Boc-Ala-Phe-OH	FMOC-N-Me-D-Phe-OH	HD-Phe-OMe·HCl	Boc-4-NO2-D-Phe-OEt
Fmoc-β-Ala-D-phe	Fmoc-Phe-Cl	HL-Phe-OMe.HCl	Boc-D,L-Phe(4-NO2)-OH
Leu-Phe.Hcl	Fmoc-Phe(4-NO2)-OH	H-DL-Phe-OBzl .tos	Fmoc-Phe-Phe-OH
Boc-Leu-Phe	Cbz-L-Phe-OH	H-DL-Phe(4-NO2)-OH.H2O	Fmoc-Phe-Gly-OH
Cbz-L-Phe-Leu-OH	Cbz-D-Phe-OH	HL-Phe-OBzl.HCl	Fmoc-D-Phe(4-NO2)-OH
L-Phe	Cbz-DL-Phe-OH	HL-Phe-OEt.HCl	Cbz-Phe-Arg-OH
HD-Phe-OH	Cbz-D-Phe-OL	L-Phe-NH2	Cbz-Phe-Ala-OH
L-Phe-NCA	ZN-Me-L-Phe-OH	D-Phe-NH2	Cbz-Phe-Gly-OH
Tos-Phe	cbz-L-Phe-OSU	N-Ac-L-Phe-OH	Cbz-Phe-Met-OH
L-Phe-ol	Phe-Ala	N-AC-L-Phe-Ome	Cbz-Phe-Gly-Oet
L-Phe (4-NO2) -OH	L-Phe-Phe	N-Pht-Phe-OH	Boc-Phe-Gly-Gly-OH
L-Phe (4-NO2) .H2O	L-Phe-Trp	Boc-Phe-OH	Fmoc-L-Thr(tBu)-Phe-OH
D-Phe(4-NO2)-OH.h2o	L-Phe-Leu-OH	Boc-D-Phe-OH	D-Phe-NH2
D-Phe(4-NO2)-OH	L-Phe-Tyr-OH	Boc-DL-Phe-OH	Tyr-Phe
N-Me-D-Phe	L-Phe-Gly	BOC-N-Me-D-Phe-OH	DL-Phe-Ome.Hcl
HN-Me-L-Phe-OH	D-Phe-D-Phe	Boc-N-Me-DL-Phe-OH	Boc-Met-Leu-Phe
L-Phe.hcl	L-Phe-OBzl-OH	Boc-N-Me-L-Phe-OH	Asp-Phe-Ome
4-NO2-D-phe.hcl	D-Phe-Obzl.Tos	Boc-N-Me-L-Phe-OH.DCHA	L-Homophe-OH
HL-Phe-OtBu.HCl	Boc-Phe-Ala-OH	Boc-DN-Me-Phe•DCHA	D-Homophe-OH
HD-Phe-OtBu.HCl	Boc-Phe-Leu-OH	Boc-Phe-Ol	L-Homophe-Oet.Hcl
D,L-Phe-OtBu HCl	Boc-Phe-Trp-OH	Boc-D-Phe-Ol	D-Homophe-Oet.HCl
HD-Phe(4-NO2)-Ome.HCl	Boc-L-Phe-Tyr-OH	Boc-Phe-NH2	Boc-L-Homophe-OH
D-Phe-Obzl.Hcl	Boc-Phe-Phe-OH	Boc-L-Phe-Ome	Boc-D-Homophe-OH
DL-Phe-Ome.Hcl	Boc-D-Phe-Phe	Boc-D-Phe-Ome	Fmoc-L-HomoPhe-OH
Boc-D-Phe(4-NO2)-OH	Cbz-D-Homophe-OH	Boc-Phe-Obzl	Fmoc-D-Homophe-OH
Boc-L-Phe-OSU	Boc-Homophe-Leu-Phe-Ome	Boc-4-NO2-Phe-OH	Cbz-L-Homophe-OH
Boc-D-Phe-OSU

Sarraynta

1. Adeegga R&D waa la heli karaa
2. Soo saaraha shahaadada ISO, dammaanad tayo leh
3.Koorsada buuxda ee adeegga dabagalka inta lagu jiro wax soo saarka
4.High kharash waxtar leh
5. Dukumentiyada shahaadaynta tayada leh ee la bixiyay codsi kasta oo macmiil ah
6.Great adeegga iibka ka dib, ilaalinta xiriirka dhow ee macaamiisha
7.Khayraadka buuxa si uu u caawiyo dhimista kharashka maraakiibta
8.Muunad bilaash ah oo la bixiyo si loo hubiyo tayada ka hor lacag bixin kasta
9.Payment term gorgortanka
10.Assit macaamiisha wax ka qabtaan arrimaha Shiinaha