167393-62-6 Fmoc-L-Lys(Mtt)-OH

Wajiga adag ee Peptide Synthesis (SPPS): Gudaha SPPS, peptides waxaa lagu farsameeyaa taageero adag, sida caadiga ah resin.167393-62-6 Fmoc-L-Lys(Mtt) -OH waxaa loo isticmaalaa sidii mid ka mid ah blocks-ka dhismaha ee peptide synthesis.Kooxda Fmoc (9-fluorenylmethoxycarbonyl) waa koox ilaalin ah oo caadi ahaan loo isticmaalo SPPS si loo ilaaliyo kooxda amino acids amino, ka hortagga falcelinta aan loo baahnayn inta lagu jiro samaynta bond peptide.Kooxda Mtt (4-methyltrityl) waa koox kale oo ilaalinaysa, oo inta badan loo isticmaalo in lagu ilaaliyo kooxda epsilon amino hadhaaga lysine.Tani waxay u ogolaaneysaa ilaalinta xulashada iyo falcelinta isku-xirnaanta inta lagu jiro dhererka peptide.

Ilaalinta Xulashada: 167393-62-6 Fmoc-L-Lys(Mtt) -OH si door ah ayaa looga saari karaa xaalado khafiif ah, sida caadiga ah iyadoo la adeegsanayo aashitada sida trifluoroacetic acid (TFA).Tani waxay daaha ka qaadaysaa kooxda amino ee lysine, taas oo u oggolaanaysa inay ka qayb qaadato samaynta dammaanadda peptide oo leh asiidhka amino ee soo socda ee isku xigxiga.

Istaraatiijiyada Ilaalinta Orthogonal: 167393-62-6 Fmoc-L-Lys(Mtt) -OH waxaa badanaa loo isticmaalaa iyada oo lala kaashanayo asiidhyada kale ee Fmoc-la ilaaliyo ee kooxaha ilaalinta kala duwan si loogu oggolaado isku-darka peptides adag oo leh kooxo badan oo shaqeynaya oo la ilaaliyo.Istaraatiijiyadani waxay ku lug leedahay si xulashada ah oo loo ilaaliyo oo la isku xiro asiidhyada amino-yada gaarka ah si taxane ah oo hore loo go'aamiyay si loo dhiso silsiladda peptide ee la doonayo.

Beddelka Peptide: 167393-62-6 Fmoc-L-Lys(Mtt) -OH waxay sidoo kale u adeegi kartaa sidii gacanta wax ka beddello dheeraad ah.Ka dib isku-darka peptide-ka, kooxda Mtt si xushmad leh ayaa loo saari karaa, taasoo ka tagaysa koox amino oo bilaash ah haraaga lysine si ay ula xiriiraan molecules kale ama si ay u sii shaqeeyaan.